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Migraines likelier in men with impotence

Sunday, Apr 01 2012


Men who have been diagnosed with erectile dysfunction are 63 percent more likely to also have had a diagnosis of migraine headaches than men without the sexual disorder, according to a new study from Taiwan.

Dr. Tobias Köhler of Southern Illinois University School of Medicine, who specializes in male sexual function and fertility, told Reuters Health this is the first he’s heard of any such relationship between migraines and impotence.

“It’s an interesting first recognition of the correlation, but by no means does it mean they’re causally linked,” said Köhler, who was not involved in the new research. It’s not clear what might explain the link between erectile dysfunction (ED) and headache, although migraines have been linked to sexual dysfunction in women, the study authors note in the journal Cephalalgia.

But “no study to date has ever attempted to explore the association between migraine and ED,” write Dr. Chao-Yuan Huang at National Taiwan University’s College of Medicine and his colleagues.

It has been estimated that about 20 million men in the United States suffer from impotence.

The research team collected information on 23,000 men from a national database of insurance claims in Taiwan.

About 5,700 of the men had been diagnosed with erectile dysfunction, which is an inability to get or keep an erection.

Huang’s group then compared ED patients to 17,000 similar men who had not sought treatment for impotence.

Among the men with ED, 245, or 4.25 percent, had previously been diagnosed with migraine headaches.

In the group without ED, 457 men, or 2.64 percent, had been diagnosed with migraines.

After the researchers took into account differences between the groups, including heart disease and diabetes, they found that ED patients were 1.63 times as likely to have had a previous migraine diagnosis as men in the other group.

Age seemed to make a difference.

Men in their 30s with erectile dysfunction were about twice as likely as men without it to have a diagnosis of migraines.

The researchers could only speculate as to why migraines are more common among men with erectile dysfunction.

“As it has been demonstrated that chronic pain can cause sexual dysfunction,” the authors write, “one possible explanation for the association seen in this study may be the chronic pain associated with migraine headaches.”

Köhler, who also represents the American Urological Association regarding sexual medicine, agreed that pain is a possible explanation.

“We definitely know that pain in general is bad for erections,” he said.

The authors also offer up the brain chemical dopamine as a potential player, because it is thought to be involved in both migraine headaches and sexual function.

In addition, there’s the possibility that the findings could be due to some other factor. For instance, men who see a doctor for migraines might be more likely to seek care for erection problems too, Huang’s group notes.

Or it could be that the men diagnosed with migraines are taking medications that interfere with their sexual function, Köhler speculated.

Dr. Ege Serefoglu at Tulane University School of Medicine said that because this is the first stab at looking at the relationship between migraine and erectile dysfunction, the findings should be interpreted cautiously.

He added that the study was well conducted, but the results “need to be confirmed by other countries, other researchers, before we can really include migraine as a risk factor of erectile dysfunction or vice versa.”

SOURCE: Cephalalgia, online March 9, 2012.


Migraine and erectile dysfunction: evidence from a population-based case-control study

Results: After adjusting for hypertension, diabetes, hyperlipidaemia, renal disease, coronary heart disease, obesity, and alcohol abuse/alcohol dependence syndrome, conditional logistic regression revealed that among ED patients the odds of having been previously diagnosed with migraines was 1.63 (95% CI, 1.391.91) that of the control group. This risk was more pronounced in younger groups, with the highest risk being detected among those aged between 30 and 39 years. After adjusting for the above mentioned comorbidities, ED patients aged between 30 and 39 years were found to be at 1.98 (95% CI, 1.67 - 2.23) times the risk of controls for having been previously diagnosed with migraines.

Conclusion: We conclude that ED is associated with having been previously diagnosed with migraines, particularly in younger populations.

Chao-Yuan Huang,
Joseph J Keller,
Jau-Jiuan Sheu and
Herng-Ching Lin

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