A pill to prevent migraine?
Thursday, Jun 02 2011
The discovery of a gene for migraine holds great promise in the quest for new approaches—possibly even a pill—for preventing the disease, says a panel of experts presenting data at the annual scientific meeting of the American Headache Society. So far, there is no therapy that prevents an attack.
Guy A. Rouleau, MD, whose Canadian and British research team was first to sequence the gene for migraine last fall, says for the first time since the discovery of the triptans in the 1980s, investigators seeking to develop new migraine therapies are excited about the possibility of preventive drugs for migraine. Triptans act by constricting blood vessels in the brain which in turn inhibit pain receptors which can block migraine in some patients. They are e not considered preventative therapies.
“We may be moving toward developing about a pill that would block the brain’s pain channel that reacts to stimulation and causes pain in migraine,” says Dr. Rouleau. ‘Sequencing the gene not only allows us to understand the disease – it also opens understanding of the pain pathways that trigger migraine pain.” Dr. Rouleau is director of the CHU Sainte-Justine Research Center and Full Professor in the Department of Medicine of the Université de Montréal
"For the first time in decades, I have seen great interest by the research community,” he said, “including the private pharmaceutical industry in developing preventive migraine therapies.”
Dr. Rouleau is part of a panel on “Migraine and Genetics” devoted to discussing the implications of sequencing the gene for migraine. The session will be at 9:45 am, Friday, June3. More than 500 migraine specialists in clinical practice and research from around the world attend the annual session which this year focuses on “New Discoveries in Headache Medicine,” chaired by R. Allan Purdy, MD, of Dalhousie University in Halifax, Nova Scotia.
“The discovery of a gene for migraine with aura last fall was important because it confirms the longstanding observation that migraine “runs” in some families,” Dr. Purdy said. “The presence of genetic factors in a common form of migraine holds promise for developing an effective treatment.”
Some 36 million Americans suffer from migraine, more than have asthma or diabetes combined. Migraine is characterized by pulsating or throbbing headache pain which can be moderate to severe in intensity. Its severity can be extremely disabling for sufferers, painful enough to cause work loss and absence from activities with family and friends. Migraine costs the United States more than $20 billion each year. Costs are attributed to direct medical expenses (e.g. doctor visits, medications) and indirect expenses (e.g. missed work, lost productivity).
ABOUT THE AMERICAN HEADACHE SOCIETY
The American Headache Society® (AHS) is a professional society of health care providers dedicated to the study and treatment of headache and face pain. The Society’s objectives are to promote the exchange of information and ideas concerning the causes and treatments of headache and related painful disorders. Educating physicians, health professionals and the public and encouraging scientific research are the primary functions of this organization. AHS activities include an annual scientific meeting, a comprehensive headache symposium, regional symposia for neurologists and family practice physicians, publication of the journal Headache and sponsorship of the AHS Committee for Headache Education (ACHE). http://www.americanheadachesociety.org
ABOUT THE AMERICAN MIGRAINE FOUNDATION
The American Migraine Foundation is a non-profit foundation supported by the American Headache Society and generous donors dedicated to the advancement of migraine research. The mission of this newly formed foundation is to support innovative research that will lead to improvement in the lives of those who suffer from migraine and other disabling headaches. (http://www.americanmigrainefoundation.org)
CONTACTS: Joyce Yaeger
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